A UFC Heavyweight Championship bout between champion Stipe Miocic and Francis Ngannou Functioned as If headliner. The episode also featured a UFC Light Heavyweight Championship bout between present champion Daniel Cormier and Volkan Oezdemir.  A welterweight bout between The Ultimate Fighter: American Top Team vs. Blackzilians welterweight winner Kamaru Usman and Emil Weber Meek was originally scheduled for UFC 219. But because of an alleged visa issue for Meek which influenced his travel schedule, the pairing was delayed and then rescheduled to this particular occasion.  However, it was shifted to UFC Fight Night: Stephens vs. Choi a day after, that took place six days prior to this event.  A welterweight bout between Abdul Razak Alhassan and Sabah Homasi was originally scheduled for UFC 219, but later altered to this occasion. The pairing met at UFC 218, when Alhassan won via a TKO.  Charles Rosa was expected to face novice Dan Ige. However, on December 22, Rosa pulled injury.  Ige stayed on the card and faced fellow newcomer Julio Arce.  Arnold Allen was expected to confront The Ultimate Fighter: Latin America 2 lightweight winner Enrique Barzola at the event. However, Allen was pulled in the fight on January 11 due to alleged visa problems which limited his ability to travel.  newcomer Matt Bessette substituted him.  Jamie Moyle was expected to face Maryna Moroz in the event. However, Moyle pulled out of the struggle through the week leading up to case citing an undisclosed injury.  In turn, advertising officials indicated that Moroz would be rescheduled for a future event.
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